ionotropic glutamate receptors — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T12406	PEPA		iGluR
	PEPA is an allosteric AMPA receptors modulator; binds to the GluA2o and GluA3o LBDs and can be utilized as an indicator of AMPA receptor heterogeneity.		iGluR
T14971	CIQ		NMDAR
	CIQ is a subunit-selective potentiator of NMDA receptors containing the NR2C or NR2D subunit. EC50 value: 2.7 μM for NR2C and 2.8 μM for NR2D.		NMDAR
T16402	Org-26576		GluR , iGluR
	Org-26576 is a positive allosteric modulator of the AMPA receptor.		GluR , iGluR
T12234	NMDA-IN-1		NMDAR
	NMDA-IN-1 is a potent and NR2B-selective antagonist of NMDA(NMDA Ki of 0.85 nM; NR2B Ca2+ influx IC50 is 9.7 nM).		NMDAR
T8920	Sepimostat		iGluR
	Sepimostat exhibits neuroprotective activity via NR2B N-methyl-D-aspartate receptor antagonism at the Ifenprodil-binding site of the NR2B subunit. Sepimostat dimethanesulfonate inhibits the Ifenprodil binding with a Ki v...		iGluR
T20993	Memantine		Others
	Memantine, an amantadine derivative with some dopaminergic effects, has been proposed as an antiparkinson agent and has may be used to treat moderate to severe Alzheimer's disease. It acts on the glutamatergic system by ...		Others
T1897	MDL-29951		NMDAR , iGluR
	MDL-29951 is a novel glycine antagonist of NMDA receptor activation.		NMDAR , iGluR
T2362	QNZ46		NMDAR , iGluR
	QNZ46 is a NR2C/NR2D-selective NMDA receptor non-competitive antagonist.		NMDAR , iGluR
T15623	JNJ-61432059		iGluR
	JNJ-61432059 is an oral active and selective negative modulator of AMPAR associated with trans-membrane AMPAR regulatory protein (TARP) γ-8 (pIC50: 9.7 for GluA1/γ-8).		iGluR
T17293	ZL006		NMDAR , iGluR
	ZL006 is an effective inhibitor of nNOS/PSD-95 interaction. ZL006 also inhibits NMDA receptor-mediated NO synthesis.		NMDAR , iGluR
T9626	Cycloleucine		NMDAR
	Cycloleucine is an antagonist of NMDA receptor associated glycine receptor with a Ki of 600 μM. Cycloleucine is also a competitive inhibitor of S-adenosyl-methionine mediated methylation with anxiolytic and cytostatic ef...		NMDAR
T7355	IC87201		Others , iGluR
	IC87201 is a nNOS-PDZ/PSD-95-PDZ inhibitor. IC87201 showed great promise in cellular experiments and animal models of ischemic stroke and pain.		Others , iGluR
T4573	Cyclothiazide		GluR
	Cyclothiazide is a benzothiadiazide that acts as a potentiator of AMPA receptorsthat potently inhibits AMPA receptor desensitization, positively modulating its response to glutamic acid (EC50 = 3.8 M).		GluR
T5522	NMDAR antagonist 1		Others , iGluR
	NMDAR antagonist 1 is an orally active, NR2B-selective NMDAR antagonist.		Others , iGluR
T8779	HBT1		GluR
	HBT1 is an AMPA receptor potentiator that induces production of brain-derived neurotrophic factor (BDNF) and exhibits little agonistic effect in primary neurons. HBT1 binds to ligand-binding domain of AMPA-R in glutamate...		GluR
TQ0233	Traxoprodil	CP101606	NMDAR , iGluR
	Traxoprodil (CP101606) is a selective NMDA antagonist and protects hippocampal neurons (IC50: 10 nM).		NMDAR , iGluR
TQ0289	LY450108		iGluR
	LY450108 is a potentiator of the AMPA receptor that can be used in Parkinson's disease studies.		iGluR
T8458	CNQX disodium		iGluR
	CNQX disodium is a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures.		iGluR
T4171	PEAQX	NVP-AAM077	NMDAR , iGluR
	PEAQX (NVP-AAM077)(NVP-AAM 077) is an effective and orally available NMDA antagonist. It can inhibit human NMDA receptors for 1A/2A(IC50: 270 nM), rather than 1A/2B(29, 600 nM).		NMDAR , iGluR
T9133	Caroverine hydrochloride	Caroverine HCL	GluR , NMDAR , iGluR
	Caroverine hydrochloride (Caroverine HCL) is a potent, competitive and reversible antagonist of NMDA and AMPA glutamate receptor. It is also an antioxidant and calcium-blocking agent that exhibits vasorelaxant action, an...		GluR , NMDAR , iGluR